As with many other Societies, The Chesapeake Colonies went through a period of economic depressiiondue to declining prices in tobacco.  This in turn led to times of great turmoil, Civil Wars, and increased division in the social and political fabric of the colony.  THese times led to a lot of colonists taking out frustrations on the local Indians.  In April 1676, Nathaniel Bacon, a relative of Virginia Governor William Berkeley, led three hundred settlers against peaceful local tribes, killing them all.  When Bacon's force grew to twelve hundred men, he decided to drive all Indian's out of the colony. 
This uprising was known as Bacon's Rebellion.  It only served to make a bad situation of economic depression, racial divide and mistrust worse.  There was also other revolts such as the ones led by Opechancanough the Algonquian Chief who,led the Indian uprising of 1622, aqqnd in 1964 killing about five hundred Virginia Colonists in two days.
By late 1680 there were fewer servants arriving in the Chesapeake.  Considering that most of the labor performed on the tobacco farms was done by these servants, this was not a welcome aspect for this colony.